[HTML][HTML] Differential cytopathogenesis of respiratory syncytial virus prototypic and clinical isolates in primary pediatric bronchial epithelial cells

R Villenave, D O'Donoghue, S Thavagnanam… - Virology Journal, 2011 - Springer
Background Human respiratory syncytial virus (RSV) causes severe respiratory disease in
infants. Airway epithelial cells are the principle targets of RSV infection. However, the …

[HTML][HTML] A 3-D well-differentiated model of pediatric bronchial epithelium demonstrates unstimulated morphological differences between asthmatic and nonasthmatic …

J Parker, S Sarlang, S Thavagnanam, G Williamson… - Pediatric …, 2010 - nature.com
There is a need for reproducible and effective models of pediatric bronchial epithelium to
study disease states such as asthma. We aimed to develop, characterize, and differentiate …

Safety and efficacy of tamoxifen in boys with Duchenne muscular dystrophy (TAMDMD): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial

BC Henzi, S Schmidt, S Nagy, D Rubino-Nacht… - The Lancet …, 2023 - thelancet.com
Background Drug repurposing could provide novel treatment options for Duchenne
muscular dystrophy. Because tamoxifen—an oestrogen receptor regulator—reduced signs …

[HTML][HTML] The use of remote video directly observed therapy to improve both inhaler technique and adherence to asthma medications

P McCrossan, D O'Donoghue, JC McElnay… - Frontiers in public …, 2022 - frontiersin.org
Incorrect inhaler technique and non-adherence to inhaled preventer therapy often is the
cause of poorly controlled asthma. Detecting and correcting non-adherence in asthma …

[HTML][HTML] Calibration of confidence and assessed clinical skills competence in undergraduate paediatric OSCE scenarios: a mixed methods study

D O'Donoghue, G Davison, LJ Hanna… - BMC medical …, 2018 - Springer
Background The relationship between confidence and competence in clinical skills
development is complex but important. This study aims to determine undergraduate …

Night-to-night variation of pulse oximetry in children with sleep-disordered breathing

RM Burke, B Maxwell, C Hunter, D Graham… - Archives of Disease in …, 2016 - adc.bmj.com
Background Sleep-disordered breathing is a common and serious feature of many
paediatric conditions and is particularly a problem in children with Down syndrome …

Use of oximetry to screen for paediatric obstructive sleep apnoea: is one night enough and is 6 hours too much?

NC Galway, B Maxwell, M Shields… - Archives of Disease in …, 2021 - adc.bmj.com
Introduction Nocturnal pulse oximetry can be used to screen for obstructive sleep apnoea
(OSA) using the McGill Oximetry Score (MOS). The MOS has a time threshold for a …

[HTML][HTML] How we teach children with asthma to use their inhaler: a scoping review

P McCrossan, O Mallon, MD Shields, C Russell… - Italian Journal of …, 2022 - Springer
Background One reason that asthma remains poorly controlled in children is poor inhaler
technique. Guidelines recommend checking inhaler technique at each clinical visit …

[HTML][HTML] Implementation of a Children's Safe Asthma Discharge Care Pathway Reduces the Risk of Future Asthma Attacks in Children–A Retrospective Quality …

L Kennedy, G Gallagher, B Maxwell… - Frontiers in …, 2022 - frontiersin.org
Abstract Background: Many children attend Emergency Departments (ED) and Out of Hours
(OoH) frequently for acute asthma. Follow up care is often suboptimal leaving these children …

[HTML][HTML] How we teach children with asthma to use their inhaler: a scoping review protocol

P McCrossan, O Mallon, MD Shields… - Systematic Reviews, 2020 - Springer
Background One reason that asthma remains poorly controlled in children is poor inhaler
technique. Current guidelines recommend checking inhaler technique at each clinical visit …