User profiles for "author:Ela Chakkarapani"

Ela Chakkarapani

Associate Professor
Verified email at bristol.ac.uk
Cited by 4938

Xenon and hypothermia combine additively, offering long-term functional and histopathologic neuroprotection after neonatal hypoxia/ischemia

C Hobbs, M Thoresen, A Tucker, K Aquilina… - Stroke, 2008 - Am Heart Assoc
Background and Purpose—Hypoxic/ischemic (HI) brain injury affects 1 to 6 per 1000 live
human births, with a mortality of 15% to 20%. A quarter of survivors have permanent …

Cooling Combined with Immediate or Delayed Xenon Inhalation Provides Equivalent Long-Term Neuroprotection after Neonatal Hypoxia—Ischemia

M Thoresen, CE Hobbs, T Wood… - Journal of Cerebral …, 2009 - journals.sagepub.com
Hypothermia (HT) improves outcome after neonatal hypoxia–ischemia. Combination therapy
may extend neuroprotection. The noble anesthetic gas xenon (Xe) has an excellent safety …

Xenon ventilation during therapeutic hypothermia in neonatal encephalopathy: a feasibility study

J Dingley, J Tooley, X Liu, E Scull-Brown, M Elstad… - …, 2014 - publications.aap.org
BACKGROUND AND OBJECTIVES: Therapeutic hypothermia has become standard of care
in newborns with moderate and severe neonatal encephalopathy; however, additional …

Lactate dehydrogenase predicts hypoxic ischaemic encephalopathy in newborn infants: a preliminary study

M Karlsson, E Wiberg‐Itzel, E Chakkarapani… - Acta …, 2010 - Wiley Online Library
Background: Enzyme leakage as a result of hypoxia‐ischaemia induced cell damage in
affected organs is seen together with hypoxic ischaemic encephalopathy (HIE) after …

[HTML][HTML] Antenatal and neonatal exposure to SARS-CoV-2 and children's development: a systematic review and meta-analysis

R Jackson, K Woodward, M Ireland, C Larkin… - Pediatric …, 2023 - nature.com
Objectives To conduct a systematic review of the impact of antenatal and neonatal exposure
to SARS-CoV-2 on developmental outcomes in preterm and term-born infants. Methods We …

School-age outcomes of children without cerebral palsy cooled for neonatal hypoxic–ischaemic encephalopathy in 2008–2010

R Lee-Kelland, S Jary, J Tonks, FM Cowan… - Archives of Disease in …, 2020 - fn.bmj.com
Objective Since therapeutic hypothermia became standard care for neonatal hypoxic–
ischaemic encephalopathy (HIE), even fewer infants die or have disability at 18-month …

[HTML][HTML] MRI combined with early clinical variables are excellent outcome predictors for newborn infants undergoing therapeutic hypothermia after perinatal asphyxia

M Thoresen, S Jary, L Walløe, M Karlsson… - …, 2021 - thelancet.com
Background Binary prediction-models for outcome [death, cognition, presence and severity
of cerebral palsy (CP)], using MRI and early clinical data applicable for individual outcome …

A comparison of cooling methods used in therapeutic hypothermia for perinatal asphyxia

N Hoque, E Chakkarapani, X Liu, M Thoresen - Pediatrics, 2010 - publications.aap.org
OBJECTIVE: The objective of this study was to compare cooling methods during therapeutic
hypothermia (TH) for moderate or severe perinatal asphyxia with regard to temperature and …

Motor performance and cognitive correlates in children cooled for neonatal encephalopathy without cerebral palsy at school age

S Jary, R Lee‐Kelland, J Tonks, FM Cowan… - Acta …, 2019 - Wiley Online Library
Aim To investigate whether motor performance in school‐age children without cerebral
palsy (CP), cooled for neonatal encephalopathy, is associated with perinatal factors and 18 …

[HTML][HTML] Development of amplitude-integrated electroencephalography and interburst interval in the rat

AM Tucker, K Aquilina, E Chakkarapani, CE Hobbs… - Pediatric …, 2009 - nature.com
Continuous monitoring of electrocortical brain activity with amplitude-integrated
electroencephalography (aEEG) is important in neonatology. aEEG is affected by, for …