The rapid evolution of drug discovery science, fuelled by combinatorial librarybased
synthesis programmes, has led to increased pressure on the drug safety evaluation process …

The composition and activity of the gut microbiota codevelop with the host from birth and is
subject to a complex interplay that depends on the host genome, nutrition, and life-style. The …

The later that a molecule or molecular class is lost from the drug development pipeline, the
higher the financial cost. Minimizing attrition is therefore one of the most important aims of a …

Although a wide range of risk factors for coronary heart disease have been identified from
population studies, these measures, singly or in combination, are insufficiently powerful to …

Metabolic profiling, metabolomic and metabonomic studies mainly involve the
multicomponent analysis of biological fluids, tissue and cell extracts using NMR …

We provide an overview of how the underlying philosophy of chemometrics is integrated
throughout metabonomic studies. Four steps are demonstrated:(1) definition of the aim,(2) …

The characteristics of the OPLS method have been investigated for the purpose of
discriminant analysis (OPLS‐DA). We demonstrate how class‐orthogonal variation can be …

Humans have evolved intimate symbiotic relationships with a consortium of gut microbes
(microbiome) and individual variations in the microbiome influence host health, may be …

Kwashiorkor, an enigmatic form of severe acute malnutrition, is the consequence of
inadequate nutrient intake plus additional environmental insults. To investigate the role of …

Here, we study the intricate relationship between gut microbiota and host cometabolic
phenotypes associated with dietary-induced impaired glucose homeostasis and …