Immunological aspects of Epstein–Barr virus infection
S Ohga, A Nomura, H Takada, T Hara - Critical reviews in oncology …, 2002 - Elsevier
Epstein–Barr virus (EBV) is a member of ubiquitous γ herpes viruses, which primarily
induces acute infectious mononucleosis (IM) or subclinical infection in susceptible subjects …
induces acute infectious mononucleosis (IM) or subclinical infection in susceptible subjects …
Flow cytometry-based diagnosis of primary immunodeficiency diseases
H Kanegane, A Hoshino, T Okano, T Yasumi… - Allergology …, 2018 - jstage.jst.go.jp
abstract Primary immunodeficiencies (PIDs) are a heterogeneous group of inherited
diseases of the immune system. The definite diagnosis of PID is ascertained by genetic …
diseases of the immune system. The definite diagnosis of PID is ascertained by genetic …
Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome
Y Minegishi, M Saito, S Tsuchiya, I Tsuge, H Takada… - Nature, 2007 - nature.com
Hyper-immunoglobulin E syndrome (HIES) is a compound primary immunodeficiency
characterized by a highly elevated serum IgE, recurrent staphylococcal skin abscesses and …
characterized by a highly elevated serum IgE, recurrent staphylococcal skin abscesses and …
Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4
Abstract Toll-like receptors (TLRs), which recognize pathogen-associated molecular
patterns, and members of the pro-inflammatory interleukin-1 receptor (IL-1R) family, share …
patterns, and members of the pro-inflammatory interleukin-1 receptor (IL-1R) family, share …
[PDF][PDF] Human tyrosine kinase 2 deficiency reveals its requisite roles in multiple cytokine signals involved in innate and acquired immunity
Y Minegishi, M Saito, T Morio, K Watanabe… - Immunity, 2006 - cell.com
Summary Tyrosine kinase 2 (Tyk2) is a nonreceptor tyrosine kinase that belongs to the
Janus kinase (Jak) family. Here we identified a homozygous Tyk2 mutation in a patient who …
Janus kinase (Jak) family. Here we identified a homozygous Tyk2 mutation in a patient who …
Clinical features and outcome of patients with IRAK-4 and MyD88 deficiency
C Picard, H Von Bernuth, P Ghandil, M Chrabieh… - Medicine, 2010 - journals.lww.com
Autosomal recessive interleukin-1 receptor-associated kinase (IRAK)-4 and myeloid
differentiation factor (MyD) 88 deficiencies impair Toll-like receptor (TLR)-and interleukin-1 …
differentiation factor (MyD) 88 deficiencies impair Toll-like receptor (TLR)-and interleukin-1 …
Selective predisposition to bacterial infections in IRAK-4–deficient children: IRAK-4–dependent TLRs are otherwise redundant in protective immunity
Human interleukin (IL) 1 receptor–associated kinase 4 (IRAK-4) deficiency is a recently
discovered primary immunodeficiency that impairs Toll/IL-1R immunity, except for the Toll …
discovered primary immunodeficiency that impairs Toll/IL-1R immunity, except for the Toll …
Interleukin-18 in hemophagocytic lymphohistiocytosis
H Takada, A Nomura, S Ohga, T Hara - Leukemia & lymphoma, 2001 - Taylor & Francis
Hemophagocytic lymphohistiocytosis (HLH) is characterized by dysregulated
hyperactivation of macrophages and T helper 1 (Th1) cells accompanied by excessive …
hyperactivation of macrophages and T helper 1 (Th1) cells accompanied by excessive …
High incidence of NLRP3 somatic mosaicism in patients with chronic infantile neurologic, cutaneous, articular syndrome: Results of an international multicenter …
Objective Chronic infantile neurologic, cutaneous, articular (CINCA) syndrome, also known
as neonatal‐onset multisystem inflammatory disease (NOMID), is a dominantly inherited …
as neonatal‐onset multisystem inflammatory disease (NOMID), is a dominantly inherited …
Identification of mutations in the c-mpl gene in congenital amegakaryocytic thrombocytopenia
K Ihara, E Ishii, M Eguchi, H Takada… - Proceedings of the …, 1999 - National Acad Sciences
Congenital amegakaryocytic thrombocytopenia (CAMT) is a rare disorder expressed in
infancy and characterized by isolated thrombocytopenia and megakaryocytopenia with no …
infancy and characterized by isolated thrombocytopenia and megakaryocytopenia with no …