The selection of appropriate outcomes or domains is crucial when designing clinical trials in
order to compare directly the effects of different interventions in ways that minimize bias. If …

The selection of appropriate outcomes is crucial when designing clinical trials in order to
compare the effects of different interventions directly. For the findings to influence policy and …

STRUCTURE OF THE GUIDELINES The original guidelines described the management of
oesophageal and gastric cancer within existing practice. This paper updates the guidance to …

The UK Medical Research Council's widely used guidance for developing and evaluating
complex interventions has been replaced by a new framework, commissioned jointly by the …

Background Robust data on patient-reported outcome measures comparing treatments for
clinically localized prostate cancer are lacking. We investigated the effects of active …

This study aimed at developing a shortened version of the EORTC QLQ-C30, one of the
most widely used health-related quality of life questionnaires in oncology, for palliative care …

Research on surgical interventions is associated with several methodological and practical
challenges of which few, if any, apply only to surgery. However, surgical evaluation is …

Background Second-line chemotherapy for patients with oesophagogastric adenocarcinoma
refractory to platinum and fluoropyrimidines has not shown benefits in health-related quality …

Background The Medical Research Council published the second edition of its framework in
2006 on developing and evaluating complex interventions. Since then, there have been …

Background The use of core outcome sets (COS) ensures that researchers measure and
report those outcomes that are most likely to be relevant to users of their research. Several …