User profiles for "author:Jorge Alvarez"

Jorge I Alvarez

- Verified email at upenn.edu - Cited by 8646

Jorge Alex Alvarez

- Verified email at post.harvard.edu - Cited by 1602

The Hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescence

JI Alvarez, A Dodelet-Devillers, H Kebir, I Ifergan… - Science, 2011 - science.org
The blood-brain barrier (BBB) is composed of tightly bound endothelial cells (ECs) and
perivascular astrocytes that regulate central nervous system (CNS) homeostasis. We …

Hypersensitivity cases associated with drug-eluting coronary stents: a review of available cases from the Research on Adverse Drug Events and Reports (RADAR) …

JR Nebeker, R Virmani, CL Bennett, JM Hoffman… - Journal of the American …, 2006 - jacc.org
Objectives: We undertook the review of all available cases of hypersensitivity reactions after
placement of a drug-eluting stent (DES) and classified potential causes. Background: Six …

Glial influence on the blood brain barrier

JI Alvarez, T Katayama, A Prat - Glia, 2013 - Wiley Online Library
The Blood Brain Barrier (BBB) is a specialized vascular structure tightly regulating central
nervous system (CNS) homeostasis. Endothelial cells are the central component of the BBB …

Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor

V Rothhammer, ID Mascanfroni, L Bunse… - Nature medicine, 2016 - nature.com
Astrocytes have important roles in the central nervous system (CNS) during health and
disease. Through genome-wide analyses we detected a transcriptional response to type I …

Microglial control of astrocytes in response to microbial metabolites

V Rothhammer, DM Borucki, EC Tjon, MC Takenaka… - Nature, 2018 - nature.com
Microglia and astrocytes modulate inflammation and neurodegeneration in the central
nervous system (CNS),–. Microglia modulate pro-inflammatory and neurotoxic activities in …

Preferential recruitment of interferon‐γ–expressing TH17 cells in multiple sclerosis

H Kebir, I Ifergan, JI Alvarez, M Bernard… - Annals of Neurology …, 2009 - Wiley Online Library
Objective There is substantial evidence supporting the role of interferon (IFN)‐γ–producing T
helper (TH) 1 and interleukin (IL)‐17–expressing TH17 lymphocytes in multiple sclerosis …

[HTML][HTML] Global monitoring of antimicrobial resistance based on metagenomics analyses of urban sewage

RS Hendriksen, P Munk, P Njage, B Van Bunnik… - Nature …, 2019 - nature.com
Antimicrobial resistance (AMR) is a serious threat to global public health, but obtaining
representative data on AMR for healthy human populations is difficult. Here, we use …

[HTML][HTML] How do immune cells overcome the blood–brain barrier in multiple sclerosis?

C Larochelle, JI Alvarez, A Prat - FEBS letters, 2011 - Elsevier
The presence of the blood–brain barrier (BBB) restricts the movement of soluble mediators
and leukocytes from the periphery to the central nervous system (CNS). Leukocyte entry into …

Anthracycline associated cardiotoxicity in survivors of childhood cancer

SE Lipshultz, JA Alvarez, RE Scully - Heart, 2008 - heart.bmj.com
The development of effective antineoplastic therapies for childhood cancer is a great
success in modern medicine. Five year survival rates of children diagnosed with cancer in …

Regulation of astrocyte activation by glycolipids drives chronic CNS inflammation

L Mayo, SA Trauger, M Blain, M Nadeau, B Patel… - Nature medicine, 2014 - nature.com
Astrocytes have complex roles in health and disease, thus it is important to study the
pathways that regulate their function. Here we report that lactosylceramide (LacCer) …