Pharmacological considerations for tenofovir and emtricitabine to prevent HIV infection

PL Anderson, JJ Kiser, EM Gardner… - Journal of …, 2011 - academic.oup.com
The use of antiretroviral medications in HIV-negative individuals as pre-exposure
prophylaxis (PrEP) is a promising approach to prevent HIV infection. Tenofovir disoproxil …

Tenofovir, emtricitabine, and tenofovir diphosphate in dried blood spots for determining recent and cumulative drug exposure

JR Castillo-Mancilla, JH Zheng, JE Rower… - AIDS research and …, 2013 - liebertpub.com
Tenofovir (TFV) disoproxil fumarate (TDF)±emtricitabine (FTC) are widely used for HIV
treatment and chemoprophylaxis, but variable adherence may lead to suboptimal …

Determination of nucleoside analog mono-, di-, and tri-phosphates in cellular matrix by solid phase extraction and ultra-sensitive LC–MS/MS detection

LR Bushman, JJ Kiser, JE Rower, B Klein… - … of pharmaceutical and …, 2011 - Elsevier
An ultra-sensitive liquid chromatography tandem mass spectrometry (LC–MS/MS) assay
was developed and validated to facilitate the assessment of clinical pharmacokinetics of …

[HTML][HTML] Evaluation of sulfobutylether-β-cyclodextrin (SBECD) accumulation and voriconazole pharmacokinetics in critically ill patients undergoing continuous renal …

TH Kiser, DN Fish, CL Aquilante, JE Rower… - Critical Care, 2015 - Springer
Introduction Intravenous (IV) voriconazole is not recommended in patients with creatinine
clearance< 50 ml/min to avoid potentially toxic accumulation of sulfobutylether-β …

Intracellular tenofovir and emtricitabine anabolites in genital, rectal, and blood compartments from first dose to steady state

SM Seifert, X Chen, AL Meditz… - AIDS research and …, 2016 - liebertpub.com
The pharmacokinetics (PK) of tenofovir-diphosphate (TFV-DP) and emtricitabine-
triphosphate (FTC-TP), the active anabolites of tenofovir disoproxil fumarate (TDF), and …

Optimizing the use of intravenous magnesium sulfate for acute asthma treatment in children

X Liu, T Yu, JE Rower, SC Campbell… - Pediatric …, 2016 - Wiley Online Library
Background Asthma is the most common pediatric chronic disease and currently affects 7.1
million children in the United States. Many children experience acute asthma exacerbations …

Pharmacodynamic studies of voriconazole: informing the clinical management of invasive fungal infections

KM Job, J Olson, C Stockmann… - Expert review of anti …, 2016 - Taylor & Francis
Introduction: Voriconazole is a broad-spectrum antifungal agent commonly used to treat
invasive fungal infections (IFI), including aspergillosis, candidiasis, Scedosporium infection …

[HTML][HTML] Zidovudine and lamivudine for HIV infection

PL Anderson, JE Rower - Clinical medicine reviews in therapeutics, 2010 - ncbi.nlm.nih.gov
Zidovudine and lamivudine (ZDV and 3TC) are long-standing nucleoside analog-reverse
transcriptase inhibitors (NRTIs) with extensive clinical experience in a wide spectrum of …

A population pharmacokinetic-pharmacogenetic analysis of atazanavir

DA Kile, S MaWhinney, CL Aquilante… - AIDS research and …, 2012 - liebertpub.com
Atazanavir is a first-line HIV protease inhibitor commonly co-dosed with ritonavir. Ritonavir
inhibits atazanavir metabolism, decreasing variability and increasing plasma concentrations …

Impact of the CYP2C8 *3 polymorphism on the drug–drug interaction between gemfibrozil and pioglitazone

CL Aquilante, LA Kosmiski, DWA Bourne… - British journal of …, 2013 - Wiley Online Library
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT• A drug–drug interaction exists
between gemfibrozil (CYP2C8 inhibitor) and pioglitazone (CYP2C8 substrate), whereby …