User profiles for "author:Leonid Lecca"

Leonid Lecca

Socios En Salud
Verified email at pih.org
Cited by 3553

[HTML][HTML] Tuberculosis and chronic respiratory disease: a systematic review

AL Byrne, BJ Marais, CD Mitnick, L Lecca… - International Journal of …, 2015 - Elsevier
Background Chronic respiratory disease causes substantial global morbidity and mortality.
The contribution of pulmonary tuberculosis to the aetiology of chronic respiratory disease is …

[HTML][HTML] Vitamin D status and risk of incident tuberculosis disease: A nested case-control study, systematic review, and individual-participant data meta-analysis

O Aibana, CC Huang, S Aboud, A Arnedo-Pena… - PLoS …, 2019 - journals.plos.org
Background Few studies have evaluated the association between preexisting vitamin D
deficiency and incident tuberculosis (TB). We assessed the impact of baseline vitamins D …

Single-cell eQTL models reveal dynamic T cell state dependence of disease loci

A Nathan, S Asgari, K Ishigaki, C Valencia, T Amariuta… - Nature, 2022 - nature.com
Non-coding genetic variants may cause disease by modulating gene expression. However,
identifying these expression quantitative trait loci (eQTLs) is complicated by differences in …

Multimodally profiling memory T cells from a tuberculosis cohort identifies cell state associations with demographics, environment and disease

A Nathan, JI Beynor, Y Baglaenko, S Suliman… - Nature …, 2021 - nature.com
Multimodal T cell profiling can enable more precise characterization of elusive cell states
underlying disease. Here, we integrated single-cell RNA and surface protein data from …

Impact of vitamin A and carotenoids on the risk of tuberculosis progression

O Aibana, MF Franke, CC Huang… - Clinical Infectious …, 2017 - academic.oup.com
Background Low and deficient levels of vitamin A are common in low-and middle-income
countries where tuberculosis burden is high. We assessed the impact of baseline levels of …

Efficacy and safety of high-dose rifampin in pulmonary tuberculosis. A randomized controlled trial

GE Velásquez, MB Brooks, JM Coit… - American journal of …, 2018 - atsjournals.org
Rationale: We examined whether increased rifampin doses could shorten standard therapy
for tuberculosis without increased toxicity. Objectives: To assess the differences across three …

Safety of treatment regimens containing bedaquiline and delamanid in the endTB cohort

C Hewison, U Khan, M Bastard… - Clinical Infectious …, 2022 - academic.oup.com
Background Safety of treatment for multidrug-resistant tuberculosis (MDR/RR-TB) can be an
obstacle to treatment completion. Evaluate safety of longer MDR/RR-TB regimens …

Culture conversion in patients treated with bedaquiline and/or delamanid. A prospective multicountry study

MF Franke, P Khan, C Hewison, U Khan… - American journal of …, 2021 - atsjournals.org
Rationale: Bedaquiline and delamanid offer the possibility of more effective and less toxic
treatment for multidrug-resistant (MDR) tuberculosis (TB). With this treatment, however …

A positively selected FBN1 missense variant reduces height in Peruvian individuals

S Asgari, Y Luo, A Akbari, GM Belbin, X Li, DN Harris… - Nature, 2020 - nature.com
On average, Peruvian individuals are among the shortest in the world. Here we show that
Native American ancestry is associated with reduced height in an ethnically diverse group of …

Identifying hotspots of multidrug-resistant tuberculosis transmission using spatial and molecular genetic data

JL Zelner, MB Murray, MC Becerra… - The Journal of …, 2016 - academic.oup.com
Background. We aimed to identify and determine the etiology of “hotspots” of concentrated
multidrug-resistant tuberculosis (MDR-tuberculosis) risk in Lima, Peru. Methods. From 2009 …