User profiles for "author:Leonid Lecca"
Leonid LeccaSocios En Salud Verified email at pih.org Cited by 3553 |
[HTML][HTML] Tuberculosis and chronic respiratory disease: a systematic review
Background Chronic respiratory disease causes substantial global morbidity and mortality.
The contribution of pulmonary tuberculosis to the aetiology of chronic respiratory disease is …
The contribution of pulmonary tuberculosis to the aetiology of chronic respiratory disease is …
[HTML][HTML] Vitamin D status and risk of incident tuberculosis disease: A nested case-control study, systematic review, and individual-participant data meta-analysis
Background Few studies have evaluated the association between preexisting vitamin D
deficiency and incident tuberculosis (TB). We assessed the impact of baseline vitamins D …
deficiency and incident tuberculosis (TB). We assessed the impact of baseline vitamins D …
Single-cell eQTL models reveal dynamic T cell state dependence of disease loci
Non-coding genetic variants may cause disease by modulating gene expression. However,
identifying these expression quantitative trait loci (eQTLs) is complicated by differences in …
identifying these expression quantitative trait loci (eQTLs) is complicated by differences in …
Multimodally profiling memory T cells from a tuberculosis cohort identifies cell state associations with demographics, environment and disease
Multimodal T cell profiling can enable more precise characterization of elusive cell states
underlying disease. Here, we integrated single-cell RNA and surface protein data from …
underlying disease. Here, we integrated single-cell RNA and surface protein data from …
Impact of vitamin A and carotenoids on the risk of tuberculosis progression
Background Low and deficient levels of vitamin A are common in low-and middle-income
countries where tuberculosis burden is high. We assessed the impact of baseline levels of …
countries where tuberculosis burden is high. We assessed the impact of baseline levels of …
Efficacy and safety of high-dose rifampin in pulmonary tuberculosis. A randomized controlled trial
GE Velásquez, MB Brooks, JM Coit… - American journal of …, 2018 - atsjournals.org
Rationale: We examined whether increased rifampin doses could shorten standard therapy
for tuberculosis without increased toxicity. Objectives: To assess the differences across three …
for tuberculosis without increased toxicity. Objectives: To assess the differences across three …
Safety of treatment regimens containing bedaquiline and delamanid in the endTB cohort
C Hewison, U Khan, M Bastard… - Clinical Infectious …, 2022 - academic.oup.com
Background Safety of treatment for multidrug-resistant tuberculosis (MDR/RR-TB) can be an
obstacle to treatment completion. Evaluate safety of longer MDR/RR-TB regimens …
obstacle to treatment completion. Evaluate safety of longer MDR/RR-TB regimens …
Culture conversion in patients treated with bedaquiline and/or delamanid. A prospective multicountry study
Rationale: Bedaquiline and delamanid offer the possibility of more effective and less toxic
treatment for multidrug-resistant (MDR) tuberculosis (TB). With this treatment, however …
treatment for multidrug-resistant (MDR) tuberculosis (TB). With this treatment, however …
A positively selected FBN1 missense variant reduces height in Peruvian individuals
On average, Peruvian individuals are among the shortest in the world. Here we show that
Native American ancestry is associated with reduced height in an ethnically diverse group of …
Native American ancestry is associated with reduced height in an ethnically diverse group of …
Identifying hotspots of multidrug-resistant tuberculosis transmission using spatial and molecular genetic data
Background. We aimed to identify and determine the etiology of “hotspots” of concentrated
multidrug-resistant tuberculosis (MDR-tuberculosis) risk in Lima, Peru. Methods. From 2009 …
multidrug-resistant tuberculosis (MDR-tuberculosis) risk in Lima, Peru. Methods. From 2009 …