Cystic fibrosis (CF) is a life-limiting disease characterised by recurrent respiratory infections,
inflammation and lung damage. The volume and composition of the airway surface liquid …

Asthma is the the most common chronic respiratory condition of childhood worldwide, with
around 14% of children and young people affected. Despite the high prevalence, paediatric …

Cystic fibrosis is the most common genetically determined, life-limiting disorder in
populations of European ancestry. The genetic basis of cystic fibrosis is well established to …

The nasal epithelium is a plausible entry point for SARS-CoV-2, a site of pathogenesis and
transmission, and may initiate the host response to SARS-CoV-2. Antiviral interferon (IFN) …

Objective To report the oral corticosteroid-sparing effect of omalizumab in children with
severe asthma. Design 16-week therapeutic trial. Setting Tertiary paediatric asthma clinic …

Objectives: To measure the neonatal autopsy rate at a tertiary referral centre and identify
trends over the past decade. To identify factors that may influence the likelihood of consent …

Background The presence of co-morbidities, including underlying respiratory problems, has
been identified as a risk factor for severe COVID-19 disease. Information on the clinical …

Chronic pulmonary colonization with bacterial pathogens, particularly Pseudomonas
aeruginosa, is the primary cause of morbidity and mortality in patients with cystic fibrosis …

Rationale: Ceramide accumulates in the airway epithelium of mice deficient in cystic fibrosis
transmembrane conductance regulator, resulting in susceptibility to Pseudomonas …

Objectives Patients with cystic fibrosis are characterized by an increased risk of nutrient
malabsorption and inflammation, which may influence body composition. We examined the …