Obstruction of the central airways is an important cause of exercise-induced inspiratory
symptoms (EIIS) in young and otherwise healthy individuals. This is a large, heterogeneous …

Objective To evaluate the effects and safety of exercise training, and to determine the most
effective exercise intervention for people with Duchenne muscular dystrophy. Exercise …

Background As a result of advances in perinatal care, more small preterm infants survive.
There are concerns that preterm birth and its treatments may harm pulmonary development …

When the ability to cough is impaired, secretion clearance may be assisted and augmented
with mechanical insufflation-exsufflation (MI-E). In some individuals, the efficacy of MI-E may …

Background Most patients with amyotrophic lateral sclerosis (ALS) are treated with
mechanical insufflation–exsufflation (MI-E) in order to improve cough. This method often fails …

Rationale: Lifetime respiratory function after extremely preterm birth (gestational age≤ 28
wk or birth weight≤ 1,000 g) is unknown. Objectives: To compare changes from 18–25 …

Background Lifelong pulmonary consequences of being born extremely preterm or with
extremely low birth weight remain unknown. We aimed to describe lung function trajectories …

Rationale: Extremely preterm (EP) birth is associated with a series of adverse health
outcomes, some of which may be alleviated by improved physical fitness. However, EP-born …

Objective Compare respiratory health in children born extremely preterm (EP) or with
extremely low birthweight (ELBW) nearly one decade apart, hypothesizing that better …

BACKGROUND: Respiratory complications represent the major cause of death in
amyotrophic lateral sclerosis (ALS). Noninvasive respiratory support is the mainstay therapy …