▪ Abstract The interaction of light within tissue has been used to recognize disease since the
mid-1800s. The recent developments of small light sources, detectors, and fiber optic probes …

Fiber optic probes are a key element for biomedical spectroscopic sensing. We review the
use of fiber optic probes for optical spectroscopy, focusing on applications in turbid media …

Optical spectroscopy has been extensively studied as a potential in vivo diagnostic tool that
can provide information about both the chemical and morphologic structure of tissue in near …

Recent developments in photonic technology provide the ability to noninvasively image cells
in vivo; these new cellular imaging technologies have the potential to dramatically improve …

Objective: To quantify by meta-analysis the performance of colposcopy to set a standard
against which new technologies can be compared. Data Sources: MEDLINE was searched …

Objective: At 380 nm excitation, cervical tissue fluorescence spectra demonstrate
characteristic changes with both patient age and the presence of dysplasia. A Monte Carlo …

Despite the importance of early diagnosis and treatment of HIV, only a small fraction of HIV-
exposed infants in low-and middle-income countries are tested for the disease. The gold …

A number of noninvasive fiber optic optical technologies are under development for real-
time diagnosis of neoplasia. We investigate how the light scattering properties of cervical …

New colloidal materials that can generate heat upon irradiation are being explored for
photothermal therapy as a minimally invasive approach to cancer treatment. The near …

This study evaluates the potential of near-infrared Raman spectroscopy for in vivo detection
of squamous dysplasia, a precursor to cervical cancer. A pilot clinical trial was carried out at …