The anticancer drug docetaxel (Taxotere) is formulated in the nonionic surfactant
polysorbate 80 (Tween 80). Early in the clinical development of docetaxel, it became clear …

Ulcerative colitis (UC) is an inflammatory bowel disease (IBD) of unknown etiology, probably
caused by a combination of genetic and environmental factors. The treatment of patients …

Pharmacometrics is a multidisciplinary field utilizing mathematical models of physiology,
pharmacology, and disease to describe and quantify the interactions between medication …

Background & Aims It is not clear why some patients with ulcerative colitis (UC) do not
respond to treatment with anti-tumor necrosis factor (TNF) agents, such as infliximab. It could …

Background In preclinical work and retrospective population studies, the anti-diabetic drug
metformin has been associated with antineoplastic activity and decreased burden of many …

In mycophenolate mofetil (MMF)-treated organ transplant recipients, lower mycophenolic
acid (MPA) plasma concentrations have been found in cyclosporine (CsA) compared with …

The benefits of a pharmacy-based, active therapeutic drug monitoring (TDM) service (ATM)
on outcomes were examined in a prospective study at four hospitals. ATM involved …

Background. We hypothesized that a high within-patient variability in clearance of tacrolimus
and mycophenolate mofetil (MMF) would put patients at risk for periods of over-or …

Importance Continuous morphine infusion as standard postoperative analgesic therapy in
young infants is associated with unwanted adverse effects such as respiratory depression …

Large between-and within-patient variability has been observed in the pharmacokinetics of
mycophenolic acid (MPA). However, conflicting results exist about the influence of patient …