Neuroproteomics approach and neurosystems biology analysis: ROCK inhibitors as promising therapeutic targets in neurodegeneration and neurotrauma

M Raad, T El Tal, R Gul, S Mondello, Z Zhang… - …, 2012 - Wiley Online Library
Several common degenerative mechanisms and mediators underlying the neuronal injury
pathways characterize several neurodegenerative diseases including Alzheimer's …

Predictors of severe illness in children with multisystem inflammatory syndrome after SARS-CoV-2 infection: a multicentre cohort study

J Merckx, S Cooke, T El Tal, A Bitnun, SK Morris… - CMAJ, 2022 - Can Med Assoc
Background: SARS-CoV-2 infection can lead to multisystem inflammatory syndrome in
children (MIS-C). We sought to investigate risk factors for admission to the intensive care unit …

[HTML][HTML] Pediatric inflammatory multisystem syndrome temporally associated with COVID-19: a spectrum of diseases with many names

H Tam, T El Tal, E Go, RSM Yeung - Cmaj, 2020 - Can Med Assoc
E1094 CMAJ| SEPTEMBER 21, 2020| VOLUME 192| ISSUE 38 with positive results for
SARS-CoV-2 testing are asymptomatic or have mild disease during the acute infectious …

[HTML][HTML] Paediatric inflammatory multisystem syndrome in Canada: population-based surveillance and role of SARS-CoV-2 linkage

T El Tal, MP Morin, SK Morris, DS Farrar… - Pediatric …, 2023 - nature.com
Background Paediatric inflammatory multisystem syndrome (PIMS) is a rare condition
temporally associated with SARS-CoV-2 infection. Using national surveillance data, we …

[HTML][HTML] Risk factors for severe PCR-positive SARS-CoV-2 infection in hospitalised children

T Schober, C Caya, M Barton, A Bayliss… - BMJ paediatrics …, 2022 - ncbi.nlm.nih.gov
Original research: Risk factors for severe PCR-positive SARS-CoV-2 infection in hospitalised
children - PMC Back to Top Skip to main content NIH NLM Logo Access keys NCBI Homepage …

Thrombosis and hemorrhage experienced by hospitalized children with SARS‐CoV‐2 infection or MIS‐C: Results of the PICNIC registry

S Tehseen, S Williams, J Robinson… - Pediatric Blood & …, 2022 - Wiley Online Library
Introduction Coagulopathy and thrombosis associated with SARS‐CoV‐2 infection are well
defined in hospitalized adults and leads to adverse outcomes. Pediatric studies are limited …

[HTML][HTML] Infants hospitalized for acute COVID-19: disease severity in a multicenter cohort study

J Merckx, SK Morris, A Bitnun, P Gill, T El Tal… - European journal of …, 2022 - Springer
Age is the most important determinant of COVID-19 severity. Infectious disease severity by
age is typically J-shaped, with infants and the elderly carrying a high burden of disease. We …

Neurological involvement in hospitalized children with SARS-CoV-2 infection: a multinational study

C Yea, M Barton, A Bitnun, SK Morris… - Canadian Journal of …, 2024 - cambridge.org
Background and Objectives: Neurological involvement associated with SARS-CoV-2
infection is increasingly recognized. However, the specific characteristics and prevalence in …

Consensus approach to a treat-to-target strategy in juvenile idiopathic arthritis care: report from the 2020 PR-COIN consensus conference

T El Tal, ME Ryan, BM Feldman, CA Bingham… - The Journal of …, 2022 - jrheum.org
Objective Treat to target (T2T) is a strategy of adjusting treatment until a target is reached. An
international task force recommended T2T for juvenile idiopathic arthritis (JIA) treatment …

Multicenter cohort study of multisystem inflammatory syndrome in children (MIS-C)

J Merckx, S Cooke, TE Tal, RM Laxer, A Bitnun… - medRxiv, 2021 - medrxiv.org
BACKGROUND SARS-CoV-2 infection can lead to multisystem inflammatory syndrome in
children (MIS-C). We investigated risk factors for severe disease and explored changes in …