Background Whole-exome sequencing has transformed gene discovery and diagnosis in
rare diseases. Translation into disease-modifying treatments is challenging, particularly for …

Background Headaches affect most children and rank third among illness-related causes of
school absenteeism. Although the short-term outcome for most children appears favorable …

We identified biallelic mutations in NANS, the gene encoding the synthase for N-
acetylneuraminic acid (NeuNAc; sialic acid), in nine individuals with infantile-onset severe …

Background: SARS-CoV-2 infection can lead to multisystem inflammatory syndrome in
children (MIS-C). We sought to investigate risk factors for admission to the intensive care unit …

Background Descriptions of the COVID-19 pandemic's indirect consequences on children
are emerging. We aimed to describe the impacts of the pandemic on children with medical …

Acetylation of the lysine residues in histones and other DNA-binding proteins plays a major
role in regulation of eukaryotic gene expression. This process is controlled by histone …

Knowledge synthesis constitutes a key part of evidence-based medicine and a scoping
review is a type of knowledge synthesis that maps the breadth of literature on a topic …

Background The COVID‐19 pandemic and subsequent public health restrictions created
significant challenges for children with neurodevelopmental disabilities with medical …

Pain experiences of youth with brain-based developmental disabilities are often overlooked
and/or misinterpreted, increasing the risk for poor or inadequate pain assessment and …

Original research: Risk factors for severe PCR-positive SARS-CoV-2 infection in hospitalised
children - PMC Back to Top Skip to main content NIH NLM Logo Access keys NCBI Homepage …