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Review
Helicobacter pylori infection in children
  1. Idalmis Aguilera Matos1,
  2. Sarah Esther Diaz Oliva1,
  3. Angel A Escobedo2,
  4. Oscar Manuel Villa Jiménez3,
  5. Yamila del Carmen Velazco Villaurrutia1
  1. 1Pediatric Gastroenterology, Institute of Gastroenterology, Havana, Cuba
  2. 2Epidemiology, Institute of Gastroenterology, Havana City, Havana, Cuba
  3. 3Research department, Institute of Gastroenterology, Havana, Cuba
  1. Correspondence to MD Idalmis Aguilera Matos; idaguilera{at}infomed.sld.cu

Abstract

Helicobacter pylori infection affects more than half of the world population and it occurs generally in childhood. It is associated with gastroduodenal ulcer, gastric atrophy, intestinal metaplasia, gastric adenocarcinoma and lymphoid tissue-associated lymphoma. It is difficult to eradicate this bacterium due to its high antimicrobial resistance. In children, the infection is asymptomatic in the majority of cases and complications are less common. Probable inverse relationships with allergic diseases and inflammatory bowel diseases are being studied. These reasons mean that the decision to diagnose and treat the infection in children is only considered in specific circumstances in which it provides true benefits. This review focuses on some current considerations regarding epidemiology, diagnosis and treatment of childhood infection, emphasising outcomes and treatment schemes in children.

  • gastroenterology
http://creativecommons.org/licenses/by-nc/4.0/

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

https://doi.org/10.1136/bmjpo-2020-000679

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    Footnotes

    • Contributors The following document includes the participation of each author in the manuscript. Everything was recorded on the basis of the joint decision. IA-M: planned the study, searched and selecting articles in the PubMed and Cochrane Library search engines, performed analysis and interpretation of data, writing of the manuscript, approval of final version and responsible for overall content. SED-O: searched and selecting articles in the PubMed and Cochrane Library search engines, performed analysis and interpretation of data, writing of the manuscript and approval of final version. AAE: searched and selecting articles in the PubMed and Cochrane Library search engines, approval of final version and manuscript review. OMVJ: searched and selecting articles in the PubMed and Cochrane Library search engines, writing of the manuscript and approval of final version. YdCVV: writing of the manuscript and approval of final version.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests None declared.

    • Patient consent for publication Not required.

    • Provenance and peer review Commissioned; externally peer reviewed.

    • Data availability statement Data sharing not applicable as no datasets generated and/or analysed for this study. There are no data in this work.